Withhold MONJUVI based on the severity of the adverse reaction. Consider granulocyte colony-stimulating factor (G-CSF) administration. Monitor patients with neutropenia for signs of infection. Monitor complete blood counts (CBC) prior to administration of each treatment cycle and throughout treatment. Neutropenia led to treatment discontinuation in 3.7% of patients. Grade 4 neutropenia occurred in 25% and thrombocytopenia in 6%. In L-MIND, Grade 3 neutropenia occurred in 25% of patients, thrombocytopenia in 12%, and anemia in 7%. ![]() MONJUVI can cause serious or severe myelosuppression, including neutropenia, thrombocytopenia, and anemia. Institute appropriate medical management. Based on the severity of the infusion-related reaction, interrupt or discontinue MONJUVI. Monitor patients frequently during infusion. Premedicate patients prior to starting MONJUVI infusion. These reactions were managed with temporary interruption of the infusion and/or with supportive medication. Signs and symptoms included fever, chills, rash, flushing, dyspnea, and hypertension. Eighty percent of infusion-related reactions occurred during cycle 1 or 2. ![]() In L-MIND, infusion-related reactions occurred in 6% of the 81 patients. Your nurse will give you extra calcium through a drip if this happens.MONJUVI can cause infusion-related reactions (IRRs). This happens if your calcium level gets low during your collection. You might feel very tired after having your stem cell collection. They are collected and frozen until after your high dose treatment. The machine filters the stem cells out of your blood. It goes through the machine and back into your body through the other drip. Your nurse puts a drip into each of your arms and attaches it to a machine. Collecting the stem cells takes 3 or 4 hours. When there are enough cells, your nurse collects them. On the collection dayĪfter your growth factor injections, you have blood tests every day to see if there are enough stem cells in your bloodstream. Sometimes you might have low doses of chemotherapy with the growth factor injections. You have daily injections of growth factor for between 5 and 10 days. Growth factors are natural proteins that make the bone marrow produce blood cells. You have injections of growth factors before, and sometimes after, the stem cell transplant. In some cancer centres, you may stay at home or in a hotel near the hospital for some of this time. It depends on your individual situation, including how quickly your blood cells recover and how well you are. ![]() You may stay in hospital for a few weeks after a stem cell transplant.
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